Sulfonium Salts as Derivatizing Agents. 3. Quantitation of the Cocaine Metabolite Benzoylecgonine in Urine Using Gas Chromatography with Ion-Pair Extraction/On-Column Alkylation*
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چکیده
منابع مشابه
Comparative Gas Chromatography of Halides Using Different Substituted Phenylboronic Acids as Derivatizing Reagents
The GC of halides (chloride, bromide and iodide) using phenylboronic acid (PBA), 4-bromophenylboronic acid (BPBA), 3, 5 bis (trifluoromethyl) phenylboronic acid (FPBA) and 2,4- dichlorophenylboronic acid (CPBA) as derivatizing reagents are compared. The reactions are carried out in the presence of mercuric salts. The detection systems used are FID and ECD. The thermal analysis of the compou...
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The 125I-radioimmunoassay (RIA) for benzylecgonine (cocaine metabolite) in urine was evaluated by comparison with gas-liquid chromatography (GLC) and thin-layer chromatography (TLC) and the Enzyme-Multiplied Immunoassay Technique (EMIT). By RIA, a statistically significant concentration, 2 microng/liter, was observed for urinary benzoylecgonine. The coefficient of variation for the RIA was 2.58...
متن کاملVariations in abundance of the molecular ion of the derivatized cocaine metabolite benzoylecgonine.
Benzoylecgonine (BEG) is the principal urinary metabolite of cocaine. For forensic drug testing, the presence of BEG in urine, suggested by a positive result for a screening immunoassay, must be confirmed by quantitative gas chromatographic/mass spectrometric (GC/MS) analysis, i.e., stable isotope dilution with a deuterium-labeled internal standard. GC/MS criteria for positivity also require ap...
متن کاملAn efficient synthesis of imidazolinium salts using vinyl sulfonium salts.
The synthesis of imidazolinium salts from the reaction of formamidines and (2-bromoethyl)diphenylsulfonium triflate is described. A variety of symmetrical and unsymmetrical imidazolinium triflate salts were synthesized in high yield in short reaction times under mild conditions. Aromatic and aliphatic N-substituents work well. The reaction is proposed to proceed via generation of a vinyl sulfon...
متن کاملComparison of six derivatizing agents for the determination of nine synthetic cathinones using gas chromatography-mass spectrometry
Six acylation reagents have been compared for their derivatisation potential towards nine synthetic cathinones by gas chromatography-mass spectrometry (GC-MS). The evaluated reagents were pentafluoropropionic anhydride (PFPA), trifluoroacetic anhydride (TFA), chlorodifluoroacetic anhydride (CLF2AA), heptafluorobutyric anhydride (HFBA), acetic anhydride (AA) and propionic anhydride (PA). The syn...
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ژورنال
عنوان ژورنال: Journal of Analytical Toxicology
سال: 1999
ISSN: 1945-2403,0146-4760
DOI: 10.1093/jat/23.7.581